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Subsets of non-clonal neighboring CD4(+) T cells specifically regulate the frequency of individual antigen-reactive T cells

After an immune response, the expanded population of antigen-specific CD4+ T cells contract to steady-state levels. We have found that the contraction is neither cell-autonomous nor mediated by competition for generic trophic factors, but regulated by relatively rare subsets of neighboring CD4(+) T...

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Hlavní autoři: Singh, Nevil J, Bando, Jennifer K, Schwartz, Ronald H
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478444/
https://ncbi.nlm.nih.gov/pubmed/23021952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.08.008
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