Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure

BACKGROUND: Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probe...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mbewe-Campbell, Nzali, Wei, Zhiyun, Zhang, Kuixing, Friese, Ryan S., Mahata, Manjula, Schork, Andrew J., Rao, Fangwen, Chiron, Stephane, Biswas, Nilima, Kim, Hyung-Suk, Mahata, Sushil K., Waalen, Jill, Nievergelt, Caroline M., Hook, Vivian Y., O’Connor, Daniel T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478326/
https://ncbi.nlm.nih.gov/pubmed/22871890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328356b86a
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky