Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure

BACKGROUND: Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probe...

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Main Authors: Mbewe-Campbell, Nzali, Wei, Zhiyun, Zhang, Kuixing, Friese, Ryan S., Mahata, Manjula, Schork, Andrew J., Rao, Fangwen, Chiron, Stephane, Biswas, Nilima, Kim, Hyung-Suk, Mahata, Sushil K., Waalen, Jill, Nievergelt, Caroline M., Hook, Vivian Y., O’Connor, Daniel T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478326/
https://ncbi.nlm.nih.gov/pubmed/22871890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328356b86a
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