The cytokines Interleukin 27 and Interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii a simi...

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Détails bibliographiques
Auteurs principaux: Hall, Aisling O’Hara, Beiting, Daniel P., Tato, Cristina M., John, Beena, Oldenhove, Guillaume, Lombana, Claudia Gonzalez, Pritchard, Gretchen Harms, Silver, Jonathan S., Bouladoux, Nicolas, Stumhofer, Jason S., Harris, Tajie H., Grainger, John, Wojno, Elia D. Tait, Wagage, Sagie, Roos, David S., Scott, Philip, Turka, Laurence A., Cherry, Sara, Reiner, Steven L., Cua, Daniel, Belkaid, Yasmine, Elloso, M. Merle, Hunter, Christopher A.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477519/
https://ncbi.nlm.nih.gov/pubmed/22981537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.014
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