The cytokines Interleukin 27 and Interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii a simi...

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Detalhes bibliográficos
Main Authors: Hall, Aisling O’Hara, Beiting, Daniel P., Tato, Cristina M., John, Beena, Oldenhove, Guillaume, Lombana, Claudia Gonzalez, Pritchard, Gretchen Harms, Silver, Jonathan S., Bouladoux, Nicolas, Stumhofer, Jason S., Harris, Tajie H., Grainger, John, Wojno, Elia D. Tait, Wagage, Sagie, Roos, David S., Scott, Philip, Turka, Laurence A., Cherry, Sara, Reiner, Steven L., Cua, Daniel, Belkaid, Yasmine, Elloso, M. Merle, Hunter, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477519/
https://ncbi.nlm.nih.gov/pubmed/22981537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.014
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