The cytokines Interleukin 27 and Interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii a simi...

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Autors principals: Hall, Aisling O’Hara, Beiting, Daniel P., Tato, Cristina M., John, Beena, Oldenhove, Guillaume, Lombana, Claudia Gonzalez, Pritchard, Gretchen Harms, Silver, Jonathan S., Bouladoux, Nicolas, Stumhofer, Jason S., Harris, Tajie H., Grainger, John, Wojno, Elia D. Tait, Wagage, Sagie, Roos, David S., Scott, Philip, Turka, Laurence A., Cherry, Sara, Reiner, Steven L., Cua, Daniel, Belkaid, Yasmine, Elloso, M. Merle, Hunter, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477519/
https://ncbi.nlm.nih.gov/pubmed/22981537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.014
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