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Divergence of multimodular polyketide synthases revealed by a didomain structure
The enoylreductase (ER) is the final common enzyme from modular polyketide synthases (PKSs) to be structurally characterized. The 3.0 Å resolution structure of the didomain comprised of the ketoreductase (KR) and ER from the second module of the spinosyn PKS reveals that ER shares an ~600 Å(2) inter...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477503/ https://ncbi.nlm.nih.gov/pubmed/22634636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.964 |
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