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Divergence of multimodular polyketide synthases revealed by a didomain structure

The enoylreductase (ER) is the final common enzyme from modular polyketide synthases (PKSs) to be structurally characterized. The 3.0 Å resolution structure of the didomain comprised of the ketoreductase (KR) and ER from the second module of the spinosyn PKS reveals that ER shares an ~600 Å(2) inter...

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Sonraí Bibleagrafaíochta
Main Authors: Zheng, Jianting, Gay, Darren C., Demeler, Borries, White, Mark A., Keatinge-Clay, Adrian T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477503/
https://ncbi.nlm.nih.gov/pubmed/22634636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.964
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