Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis

BACKGROUND & AIMS: GATA4, a zinc finger domain transcription factor, is critical for jejunal identity. Mice with an intestine-specific GATA4 deficiency (GATA4iKO) are resistant to diet-induced obesity and insulin resistance. Although they have decreased intestinal lipid absorption, hepatic de no...

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Autores principales: Patankar, Jay V., Obrowsky, Sascha, Doddapattar, Prakash, Hoefler, Gerald, Battle, Michele, Levak-Frank, Sanja, Kratky, Dagmar
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477492/
https://ncbi.nlm.nih.gov/pubmed/22750465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.06.028
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