Llwytho...

Ondansetron and Granisetron Binding Orientation in the 5-HT3 Receptor Determined by Unnatural Amino Acid Mutagenesis

The serotonin type 3 receptor (5-HT(3)R) is a ligand-gated ion channel that mediates fast synaptic transmission in the central and peripheral nervous systems. The 5-HT(3)R is a therapeutic target, and the clinically available drugs ondansetron and granisetron inhibit receptor activity. Their inhibit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Duffy, Noah H., Lester, Henry A., Dougherty, Dennis A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477246/
https://ncbi.nlm.nih.gov/pubmed/22873819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300246j
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