Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine(3) Receptor Revealed by Unnatural Amino Acid Mutagenesis

The mechanism by which agonist binding triggers pore opening in ligand-gated ion channels is poorly understood. Here, we used unnatural amino acid mutagenesis to introduce subtle changes to the side chains of tyrosine residues (Tyr141, Tyr143, Tyr153, and Tyr234), which dominate the 5-HT(3) receptor...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Beene, Darren L., Price, Kerry L., Lester, Henry A., Dougherty, Dennis A., Lummis, Sarah C. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730062/
https://ncbi.nlm.nih.gov/pubmed/15483128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2429-04.2004
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