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Morphine Desensitization and Cellular Tolerance Are Distinguished in Rat Locus Ceruleus Neurons

μ-Opioid receptor desensitization is considered an initial step in the development of tolerance. Curiously, the commonly used opioid morphine produces robust tolerance but minimal acute desensitization. This study was designed to test the hypothesis that desensitization is indeed present in morphine...

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Detalhes bibliográficos
Main Authors: Levitt, Erica S., Williams, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477235/
https://ncbi.nlm.nih.gov/pubmed/22914548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081547
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