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Morphine Desensitization and Cellular Tolerance Are Distinguished in Rat Locus Ceruleus Neurons

μ-Opioid receptor desensitization is considered an initial step in the development of tolerance. Curiously, the commonly used opioid morphine produces robust tolerance but minimal acute desensitization. This study was designed to test the hypothesis that desensitization is indeed present in morphine...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Levitt, Erica S., Williams, John T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477235/
https://ncbi.nlm.nih.gov/pubmed/22914548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081547
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