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Morphine Desensitization and Cellular Tolerance Are Distinguished in Rat Locus Ceruleus Neurons
μ-Opioid receptor desensitization is considered an initial step in the development of tolerance. Curiously, the commonly used opioid morphine produces robust tolerance but minimal acute desensitization. This study was designed to test the hypothesis that desensitization is indeed present in morphine...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477235/ https://ncbi.nlm.nih.gov/pubmed/22914548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081547 |
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