Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

In morphine tolerance a key question that remains to be answered is whether μ-opioid receptor (MOPr) desensitization contributes to morphine tolerance, and if so by what cellular mechanisms. Here we demonstrate that MOPr desensitization can be observed in single rat brainstem locus coeruleus (LC) ne...

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Detalhes bibliográficos
Main Authors: Bailey, C P, Llorente, J, Gabra, B H, Smith, F L, Dewey, W L, Kelly, E, Henderson, G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Synaptic Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695152/
https://ncbi.nlm.nih.gov/pubmed/19200236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2008.06573.x
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