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Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

In morphine tolerance a key question that remains to be answered is whether μ-opioid receptor (MOPr) desensitization contributes to morphine tolerance, and if so by what cellular mechanisms. Here we demonstrate that MOPr desensitization can be observed in single rat brainstem locus coeruleus (LC) ne...

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Autors principals: Bailey, C P, Llorente, J, Gabra, B H, Smith, F L, Dewey, W L, Kelly, E, Henderson, G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695152/
https://ncbi.nlm.nih.gov/pubmed/19200236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2008.06573.x
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