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Desensitization and Trafficking of μ-Opioid Receptors in Locus Ceruleus Neurons: Modulation by Kinases

The phosphorylation of μ-opioid receptors (MOPRs) by G protein-coupled receptor kinases (GRKs), followed by arrestin binding, is thought to be a key pathway leading to desensitization and internalization. The present study used the combination of intracellular and whole-cell recordings from rats and...

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Autores principales: Arttamangkul, Seksiri, Lau, Elaine K., Lu, Hsin-Wei, Williams, John T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286302/
https://ncbi.nlm.nih.gov/pubmed/22113080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076208
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