Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

Drug discovery programs increasingly are focusing on allosteric modulators as a means to modify the activity of G protein-coupled receptor (GPCR) targets. Allosteric binding sites are topographically distinct from the endogenous ligand (orthosteric) binding site, which allows for co-occupation of a...

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Main Authors: Gregory, Karen J., Noetzel, Meredith J., Rook, Jerri M., Vinson, Paige N., Stauffer, Shaun R., Rodriguez, Alice L., Emmitte, Kyle A., Zhou, Ya, Chun, Aspen C., Felts, Andrew S., Chauder, Brian A., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477233/
https://ncbi.nlm.nih.gov/pubmed/22863693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080531
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