Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

BACKGROUND: Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Disease modifying therapies targeting Aβ that are in development have been proposed to be more effective if treatment was initiated prior to significant accumulation of Aβ in the brain, but optimal timing of tre...

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Hlavní autoři: Das, Pritam, Verbeeck, Christophe, Minter, Lisa, Chakrabarty, Paramita, Felsenstein, Kevin, Kukar, Thomas, Maharvi, Ghulam, Fauq, Abdul, Osborne, Barbara A, Golde, Todd E
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477045/
https://ncbi.nlm.nih.gov/pubmed/22892055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-39
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