Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

BACKGROUND: It is well established that vaccination of humans and transgenic animals against fibrillar Aβ prevents amyloid accumulation in plaques and preserves cognitive function in transgenic mouse models. However, autoimmune side effects have halted the development of vaccines based on full lengt...

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Hauptverfasser: Rasool, Suhail, Albay, Ricardo, Martinez-Coria, Hilda, Breydo, Leonid, Wu, Jessica, Milton, Saskia, Misra, Sunit, Tran, Andy, Pensalfini, Anna, Laferla, Frank, Kayed, Rakez, Glabe, Charles G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476970/
https://ncbi.nlm.nih.gov/pubmed/22866920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-37
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