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Toward a bioengineered heparin: Challenges and strategies for metabolic engineering of mammalian cells
Heparin is the most widely used pharmaceutical to control blood coagulation in modern medicine. A health crisis that took place in 2008 led to a demand for production of heparin from non-animal sources. Since Chinese hamster ovary (CHO) cells are capable of producing heparan sulfate (HS), a related...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476871/ https://ncbi.nlm.nih.gov/pubmed/22714556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.20902 |
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