Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin

Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non-animal-derived source of this critical drug. We hypothesized that Chinese hamster ovary...

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Detalhes bibliográficos
Publicado no:Biotechnol J
Main Authors: Baik, Jong Youn, Dahodwala, Hussain, Oduah, Eziafa, Talman, Lee, Gemmill, Trent R., Gasimli, Leyla, Datta, Payel, Yang, Bo, Li, Guoyun, Zhang, Fuming, Li, Lingyun, Linhardt, Robert J., Campbell, Andrew M., Gorfien, Stephen F., Susan, T. Sharfstein
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556170/
https://ncbi.nlm.nih.gov/pubmed/26037948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201400665
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