Bioengineered Chinese Hamster Ovary Cells with Golgi-targeted 3-O-Sulfotransferase-1 Biosynthesize Heparan Sulfate with an Antithrombin-binding Site

HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involved in the biosynthesis of the antithrombin III (AT)-binding site in the biopharmaceutical drug heparin. Heparin is a highly sulfated glycosaminoglycan that shares a common biosynthetic pathway with heparan sulfate (HS...

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Bibliographic Details
Main Authors: Datta, Payel, Li, Guoyun, Yang, Bo, Zhao, Xue, Baik, Jong Youn, Gemmill, Trent R., Sharfstein, Susan T., Linhardt, Robert J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873583/
https://ncbi.nlm.nih.gov/pubmed/24247246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519033
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