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Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma

Proteasome inhibition with bortezomib is a validated approach to the treatment of multiple myeloma, but drug resistance often emerges and limits its utility in the retreatment setting. To begin to identify some of the mechanisms involved, we developed bortezomib-resistant myeloma cell lines that, un...

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Main Authors: Kuhn, Deborah J., Berkova, Zuzana, Jones, Richard J., Woessner, Richard, Bjorklund, Chad C., Ma, Wencai, Davis, R. Eric, Lin, Pei, Wang, Hua, Madden, Timothy L., Wei, Caimiao, Baladandayuthapani, Veerabhadran, Wang, Michael, Thomas, Sheeba K., Shah, Jatin J., Weber, Donna M., Orlowski, Robert Z.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476538/
https://ncbi.nlm.nih.gov/pubmed/22932796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386789
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