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A Dual Interaction between the DNA Damage Response Protein MDC1 and the RAG1 Subunit of the V(D)J Recombinase

The first step in V(D)J recombination is the formation of specific DNA double-strand breaks (DSBs) by the RAG1 and RAG2 proteins, which form the RAG recombinase. DSBs activate a complex network of proteins termed the DNA damage response (DDR). A key early event in the DDR is the phosphorylation of h...

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Detalhes bibliográficos
Main Authors: Coster, Gideon, Gold, Ayala, Chen, Darlene, Schatz, David G., Goldberg, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476314/
https://ncbi.nlm.nih.gov/pubmed/22942284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402487
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