An Engineered Disulfide Bond Reversibly Traps the IgE-Fc(3–4) in a Closed, Nonreceptor Binding Conformation

IgE antibodies interact with the high affinity IgE Fc receptor, FcϵRI, and activate inflammatory pathways associated with the allergic response. The IgE-Fc region, comprising the C-terminal domains of the IgE heavy chain, binds FcϵRI and can adopt different conformations ranging from a closed form i...

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Bibliografiske detaljer
Main Authors: Wurzburg, Beth A., Kim, Beomkyu, Tarchevskaya, Svetlana S., Eggel, Alexander, Vogel, Monique, Jardetzky, Theodore S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476292/
https://ncbi.nlm.nih.gov/pubmed/22948141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407502
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