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An Engineered Disulfide Bond Reversibly Traps the IgE-Fc(3–4) in a Closed, Nonreceptor Binding Conformation
IgE antibodies interact with the high affinity IgE Fc receptor, FcϵRI, and activate inflammatory pathways associated with the allergic response. The IgE-Fc region, comprising the C-terminal domains of the IgE heavy chain, binds FcϵRI and can adopt different conformations ranging from a closed form i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476292/ https://ncbi.nlm.nih.gov/pubmed/22948141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407502 |
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