Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction

Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-IgE single-domain antibody in complex with an IgE Fc fragment, revealing how the antibody inhibits interactions between IgE and the two receptors FcεRI...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jabs, Frederic, Plum, Melanie, Laursen, Nick S., Jensen, Rasmus K., Mølgaard, Brian, Miehe, Michaela, Mandolesi, Marco, Rauber, Michèle M., Pfützner, Wolfgang, Jakob, Thilo, Möbs, Christian, Andersen, Gregers R., Spillner, Edzard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750235/
https://ncbi.nlm.nih.gov/pubmed/29295972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02312-7
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