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Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab–Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and exp...
Enregistré dans:
| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873975/ https://ncbi.nlm.nih.gov/pubmed/27194387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11610 |
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