In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling

Replication protein A (RPA) plays essential roles in DNA metabolism, including replication, checkpoint, and repair. Recently, we described an in vitro system in which the phosphorylation of human Chk1 kinase by ATR (ataxia telangiectasia mutated and Rad3-related) is dependent on RPA bound to single-...

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Bibliographic Details
Main Authors: Lindsey-Boltz, Laura A., Reardon, Joyce T., Wold, Marc S., Sancar, Aziz
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476280/
https://ncbi.nlm.nih.gov/pubmed/22948311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407825
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