Transforming Growth Factor β Suppresses Osteoblast Differentiation via the Vimentin Activating Transcription Factor 4 (ATF4) Axis

ATF4 is an osteoblast-enriched transcription factor of the leucine zipper family. We recently identified that vimentin, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin (Ocn) transcription and osteoblast differentiation. Here we show that TGFβ inhibits...

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Detalhes bibliográficos
Main Authors: Lian, Na, Lin, Tonghui, Liu, Wenguang, Wang, Weiguang, Li, Lingzhen, Sun, Stephanie, Nyman, Jeffry S., Yang, Xiangli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476265/
https://ncbi.nlm.nih.gov/pubmed/22952236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372458
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