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Mechanistic Studies on CymD: A Tryptophan Reverse N-Prenyltransferase()

The prenyltransferase CymD catalyzes the reverse N-prenylation of tryptophan using dimethyllallyl diphosphate (DMAPP) in the biosynthesis of the cyclic peptides cyclomarin and cyclomarazine. The mechanism is of interest since a non-nucleophilic indole nitrogen must be alkylated in this process. Thre...

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Bibliografiske detaljer
Main Authors: Qian, Qi, Schultz, Andrew W., Moore, Bradley S., Tanner, Martin E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475536/
https://ncbi.nlm.nih.gov/pubmed/22935004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3009054
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