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Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides
In vitro and in vivo characterization of the cyclomarin/cyclomarazine prenyltransferase CymD revealed its ability to prenylate tryptophan prior to incorporation into both cyclic peptides by the non-ribosomal peptide synthetase CymA. This knowledge was utilized to bioengineer novel derivatives of the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846197/ https://ncbi.nlm.nih.gov/pubmed/20055491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np9006876 |
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