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Tuning of CFTR Chloride Channel Function by Location of Positive Charges within the Pore

High unitary Cl(−) conductance in the cystic fibrosis transmembrane conductance regulator Cl(−) channel requires a functionally unique, positively charged lysine residue (K95) in the inner vestibule of the channel pore. Here we used a mutagenic approach to investigate the ability of other sites in t...

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Autores principales: El Hiani, Yassine, Linsdell, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475386/
https://ncbi.nlm.nih.gov/pubmed/23083715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.09.020
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