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Hibris, a Drosophila Nephrin homologue, is required for Presenilin mediated Notch and App-like cleavages

Drosophila Hibris (Hbs), a member of the Nephrin IgG-superfamily, has been implicated in myogenesis and eye patterning. Here, we uncover a role of Hbs in Notch (N)-signaling and γ-secretase processing. Loss of hbs results in classical N-signaling associated phenotypes in Drosophila, including eye pa...

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Bibliografiske detaljer
Main Authors: Singh, Jaskirat, Mlodzik, Marek
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475182/
https://ncbi.nlm.nih.gov/pubmed/22814602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.04.021
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