Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK2 variably influence enzymatic activity...

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Main Authors: Trancikova, Alzbeta, Mamais, Adamantios, Webber, Philip J., Stafa, Klodjan, Tsika, Elpida, Glauser, Liliane, West, Andrew B., Bandopadhyay, Rina, Moore, Darren J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474772/
https://ncbi.nlm.nih.gov/pubmed/23082216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047784
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