Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation, directly participates in cancer aggressiveness, supp...

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Main Authors: De Saedeleer, Christophe J., Copetti, Tamara, Porporato, Paolo E., Verrax, Julien, Feron, Olivier, Sonveaux, Pierre
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474765/
https://ncbi.nlm.nih.gov/pubmed/23082126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046571
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