Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. By contrast, oxygenated tumor c...

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Bibliografische gegevens
Hoofdauteurs: Sonveaux, Pierre, Végran, Frédérique, Schroeder, Thies, Wergin, Melanie C., Verrax, Julien, Rabbani, Zahid N., De Saedeleer, Christophe J., Kennedy, Kelly M., Diepart, Caroline, Jordan, Bénédicte F., Kelley, Michael J., Gallez, Bernard, Wahl, Miriam L., Feron, Olivier, Dewhirst, Mark W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582933/
https://ncbi.nlm.nih.gov/pubmed/19033663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36843
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