Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. By contrast, oxygenated tumor c...

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Autores principales: Sonveaux, Pierre, Végran, Frédérique, Schroeder, Thies, Wergin, Melanie C., Verrax, Julien, Rabbani, Zahid N., De Saedeleer, Christophe J., Kennedy, Kelly M., Diepart, Caroline, Jordan, Bénédicte F., Kelley, Michael J., Gallez, Bernard, Wahl, Miriam L., Feron, Olivier, Dewhirst, Mark W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582933/
https://ncbi.nlm.nih.gov/pubmed/19033663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36843
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