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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. By contrast, oxygenated tumor c...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582933/ https://ncbi.nlm.nih.gov/pubmed/19033663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36843 |
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