Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. By contrast, oxygenated tumor c...

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Hauptverfasser: Sonveaux, Pierre, Végran, Frédérique, Schroeder, Thies, Wergin, Melanie C., Verrax, Julien, Rabbani, Zahid N., De Saedeleer, Christophe J., Kennedy, Kelly M., Diepart, Caroline, Jordan, Bénédicte F., Kelley, Michael J., Gallez, Bernard, Wahl, Miriam L., Feron, Olivier, Dewhirst, Mark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582933/
https://ncbi.nlm.nih.gov/pubmed/19033663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36843
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