Lactate does not activate NF-κB in oxidative tumor cells

The lactate anion is currently emerging as an oncometabolite. Lactate, produced and exported by glycolytic and glutaminolytic cells in tumors, can be recycled as an oxidative fuel by oxidative tumors cells. Independently of hypoxia, it can also activate transcription factor hypoxia-inducible factor-...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Van Hée, Vincent F., Pérez-Escuredo, Jhudit, Cacace, Andrea, Copetti, Tamara, Sonveaux, Pierre
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602127/
https://ncbi.nlm.nih.gov/pubmed/26528183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00228
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