Excessive activation of mTOR in postnatally-generated granule cells is sufficient to cause epilepsy

The dentate gyrus is hypothesized to function as a “gate”, limiting the flow of excitation through the hippocampus. During epileptogenesis, adult-generated granule cells (DGC) form aberrant neuronal connections with neighboring DGC, disrupting the dentate gate. Hyperactivation of the mTOR signaling...

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Hauptverfasser: Pun, Raymund Y.K., Rolle, Isaiah J., LaSarge, Candi L., Hosford, Bethany E., Rosen, Jules M., Uhl, Juli D., Schmeltzer, Sarah N., Faulkner, Christian, Bronson, Stefanie L., Murphy, Brian L., Richards, David A., Holland, Katherine D., Danzer, Steve C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474536/
https://ncbi.nlm.nih.gov/pubmed/22998871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.08.002
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