Excessive activation of mTOR in postnatally-generated granule cells is sufficient to cause epilepsy

The dentate gyrus is hypothesized to function as a “gate”, limiting the flow of excitation through the hippocampus. During epileptogenesis, adult-generated granule cells (DGC) form aberrant neuronal connections with neighboring DGC, disrupting the dentate gate. Hyperactivation of the mTOR signaling...

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Detalhes bibliográficos
Main Authors: Pun, Raymund Y.K., Rolle, Isaiah J., LaSarge, Candi L., Hosford, Bethany E., Rosen, Jules M., Uhl, Juli D., Schmeltzer, Sarah N., Faulkner, Christian, Bronson, Stefanie L., Murphy, Brian L., Richards, David A., Holland, Katherine D., Danzer, Steve C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474536/
https://ncbi.nlm.nih.gov/pubmed/22998871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.08.002
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