A Coupled Array of Noncovalent Interactions Impacts the Function of the 5-HT(3)A Serotonin Receptor in an Agonist-Specific Way

[Image: see text] The serotonin type 3A (5-HT(3)A) receptor is a Cys-loop (pentameric) neurotransmitter-gated ion channel found in the central and peripheral nervous systems and implicated in numerous diseases. In previous studies with the endogenous agonist serotonin, we identified two interactions...

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Bibliographic Details
Main Authors: Miles, Timothy F., Bower, Kiowa S., Lester, Henry A., Dougherty, Dennis A.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474281/
https://ncbi.nlm.nih.gov/pubmed/23077719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000586
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