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5-Fluorotryptamine is a partial agonist at 5-HT(3) receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function
Antagonists, but not agonists, of the 5-HT(3) receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT(3A) and 5-HT(3AB) receptors with an R(max) (I(max...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2649378/ https://ncbi.nlm.nih.gov/pubmed/18082160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.11.014 |
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