A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT(3) Receptor

[Image: see text] The binding sites of Cys-loop receptors are formed from at least six loops (A−F). Here we have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and homology modeling to probe the role of two residues in loop A of the 5-HT(3) receptor: Asn128 and Glu129. The d...

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Detalhes bibliográficos
Main Authors: Price, Kerry L., Bower, Kiowa S., Thompson, Andrew J., Lester, Henry A., Dougherty, Dennis A., Lummis, Sarah C. R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649372/
https://ncbi.nlm.nih.gov/pubmed/18498149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800222n
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