Molecular and cellular pathogenesis of hemoglobin SC disease.

Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Bunn, H F, Noguchi, C T, Hofrichter, J, Schechter, G P, Schechter, A N, Eaton, W A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1982
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6961429/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.23.7527
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