Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S.

We have previously found that the inhibitory effect of hemoglobin F (Hb F) on the polymerization of Hb S proceeds via the formation of asymmetrical hybrid tetramers of the type alpha2betasgamma. Examination of the gelling properties of binary mixtures of Hb S and several Hb variants now shows that,...

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Detalhes bibliográficos
Main Authors: Nagel, R L, Bookchin, R M, Johnson, J, Labie, D, Wajcman, H, Isaac-Sodeye, W A, Honig, G R, Schilirò, G, Crookston, J H, Matsutomo, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1979
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC383012/
https://ncbi.nlm.nih.gov/pubmed/284392
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