Molecular and cellular pathogenesis of hemoglobin SC disease.

Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bunn, H F, Noguchi, C T, Hofrichter, J, Schechter, G P, Schechter, A N, Eaton, W A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1982
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6961429/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.23.7527
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