Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S.

We have previously found that the inhibitory effect of hemoglobin F (Hb F) on the polymerization of Hb S proceeds via the formation of asymmetrical hybrid tetramers of the type alpha2betasgamma. Examination of the gelling properties of binary mixtures of Hb S and several Hb variants now shows that,...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Nagel, R L, Bookchin, R M, Johnson, J, Labie, D, Wajcman, H, Isaac-Sodeye, W A, Honig, G R, Schilirò, G, Crookston, J H, Matsutomo, K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1979
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.670
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