Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

Antibodies to the insulin receptor were prepared in BALB/c mice by immunization with IM-9 human lymphocytes, a cell type that has a large number of plasma membrane insulin receptors. The spleens of these mice were then removed, and their lymphocytes were fused to a mouse myeloma cell line, FO cells....

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Roth, R A, Cassell, D J, Wong, K Y, Maddux, B A, Goldfine, I D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1982
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6185950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.23.7312
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