Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.
Antibodies to the insulin receptor were prepared in BALB/c mice by immunization with IM-9 human lymphocytes, a cell type that has a large number of plasma membrane insulin receptors. The spleens of these mice were then removed, and their lymphocytes were fused to a mouse myeloma cell line, FO cells....
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1982
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6185950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.23.7312 |
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