Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

The metabolic actions of insulin and anti-insulin receptor monoclonal antibodies were compared with their effects on insulin receptor phosphorylation in mouse NIH 3T3 fibroblasts transfected with human insulin receptor cDNA. In serum-starved NIH 3T3 HIR3.5 cells, uptake of 2-deoxy-[3H]glucose was st...

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Detalhes bibliográficos
Main Authors: Soos, M A, O'Brien, R M, Brindle, N P, Stigter, J M, Okamoto, A K, Whittaker, J, Siddle, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC297592/
https://ncbi.nlm.nih.gov/pubmed/2546147
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