Oxidant Stress and Mitochondrial Signaling Regulate Reversible Changes of ERα Expression and Apoptosis in Aging Mouse Glomeruli and Mesangial Cells

Estrogen actions are largely dependent on the intracellular estrogen receptor (ER) levels. During aging the decline of estrogens or ER leads to a loss in antiinflammatory protection and an increase in oxidant stress due to changes in mitochondrial function. Estrogens/ER may also coordinate signaling...

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Hauptverfasser: Pereira-Simon, Simone, Xia, Xiaomei, Catanuto, Paola, Elliot, Sharon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Renal-Cardiac-Vascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473210/
https://ncbi.nlm.nih.gov/pubmed/23027807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1379
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