Testosterone and 17β-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice

Podocyte damage and apoptosis are thought to be important if not essential in the development of glomerulosclerosis. Female estrogen receptor knockout mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. Here, we studied the pathogenesis...

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Publicat a:Kidney Int
Autors principals: Doublier, Sophie, Lupia, Enrico, Catanuto, Paola, Periera-Simon, Simone, Xia, Xiaomei, Korach, Ken, Berho, Mariana, Elliot, Sharon J., Karl, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775100/
https://ncbi.nlm.nih.gov/pubmed/20962747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.398
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