Testosterone and 17β-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice

Podocyte damage and apoptosis are thought to be important if not essential in the development of glomerulosclerosis. Female estrogen receptor knockout mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. Here, we studied the pathogenesis...

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Bibliografske podrobnosti
izdano v:Kidney Int
Main Authors: Doublier, Sophie, Lupia, Enrico, Catanuto, Paola, Periera-Simon, Simone, Xia, Xiaomei, Korach, Ken, Berho, Mariana, Elliot, Sharon J., Karl, Michael
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775100/
https://ncbi.nlm.nih.gov/pubmed/20962747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.398
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